PittsburghV1, France, Analysis, bibRecord, 000091

The Amino Acid Transporter JhI-21 Coevolves with Glutamate Receptors, Impacts NMJ Physiology, and Influences Locomotor Activity in [i]Drosophila[/i] Larvae

Identifieur interne : 000091 ( France/Analysis ); précédent : 000090; suivant : 000092

The Amino Acid Transporter JhI-21 Coevolves with Glutamate Receptors, Impacts NMJ Physiology, and Influences Locomotor Activity in [i]Drosophila[/i] Larvae

Auteurs : Anna Ziegler [France] ; Hrvoje Augustin [États-Unis] ; Nathan L. Clark [États-Unis] ; Martine Berthelot-Grosjean [France] ; Mégane Simonnet [France] ; Joern R. Steinert [Royaume-Uni] ; Flore Geillon [France] ; Gérard Maniere [France] ; David E. Featherstone [États-Unis] ; Yaël Grosjean [France]

Source :

Scientific Reports [ 2045-2322 ] ; 2016.

RBID : Hal:hal-01277627

English descriptors

mix :
- evolutionary rate covariation, extracellular glutamate, genes, glial xct, in-vivo, juvenile-hormone, melanogaster, neuromuscular-junction, protein-protein interactions, synaptic vesicle.

Abstract

Changes in synaptic physiology underlie neuronal network plasticity and behavioral phenomena, which are adjusted during development. The Drosophila larval glutamatergic neuromuscular junction (NMJ) represents a powerful synaptic model to investigate factors impacting these processes. Amino acids such as glutamate have been shown to regulate Drosophila NMJ physiology by modulating the clustering of postsynaptic glutamate receptors and thereby regulating the strength of signal transmission from the motor neuron to the muscle cell. To identify amino acid transporters impacting glutmatergic signal transmission, we used Evolutionary Rate Covariation (ERC), a recently developed bioinformatic tool. Our screen identified ten proteins co-evolving with NMJ glutamate receptors. We selected one candidate transporter, the SLC7 (Solute Carrier) transporter family member JhI-21 (Juvenile hormone Inducible-21), which is expressed in Drosophila larval motor neurons. We show that JhI-21 suppresses postsynaptic muscle glutamate receptor abundance, and that JhI-21 expression in motor neurons regulates larval crawling behavior in a developmental stage-specific manner.

Url:

https://hal.archives-ouvertes.fr/hal-01277627

DOI: 10.1038/srep19692

Affiliations:

Links toward previous steps (curation, corpus...)

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to stream Main, to step Exploration: 000103
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Links to Exploration step

Hal:hal-01277627

Le document en format XML

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<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-106335" status="VALID"><idno type="RNSR">201019359D</idno>
<orgName>Centre des Sciences du Goût et de l'Alimentation [Dijon]</orgName>
<orgName type="acronym">CSGA</orgName>
<date type="start">2010-01-01</date>
<desc><address><addrLine>Université de Bourgogne - Bât. CSG - 9E Bd Jeanne d'Arc - 21000 Dijon</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www2.dijon.inra.fr/csga/</ref>
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<tutelles><tutelle name="UMR1324" active="#struct-92114" type="direct"><org type="institution" xml:id="struct-92114" status="VALID">          <orgName>Institut National de la Recherche Agronomique</orgName>
          <orgName type="acronym">INRA</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.inra.fr</ref>
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<tutelle active="#struct-300270" type="direct"><org type="institution" xml:id="struct-300270" status="VALID">          <orgName>Université de Bourgogne</orgName>
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          <desc>            <address>              <addrLine>Maison de l'université - Esplanade Érasme - BP 27877 - 21078 Dijon cedex</addrLine>
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            <ref type="url">http://www.u-bourgogne.fr/</ref>
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<tutelle name="UMR6265" active="#struct-415469" type="direct"><org type="institution" xml:id="struct-415469" status="VALID"><orgName>Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement</orgName>
<orgName type="acronym">AgroSup Dijon</orgName>
<date type="start">2009-03-01</date>
<desc><address><addrLine>26 Boulevard du Dr Petitjean - BP 87999 - 21079 Dijon cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.agrosupdijon.fr/</ref>
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<country>France</country>
<placeName><settlement type="city">Dijon</settlement>
<region type="region" nuts="2">Région Bourgogne</region>
</placeName>
<orgName type="university">Université de Bourgogne</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Bourgogne Franche-Comté</orgName>
</affiliation>
</author>
<author><name sortKey="Featherstone, David E" sort="Featherstone, David E" uniqKey="Featherstone D" first="David E." last="Featherstone">David E. Featherstone</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-451428" status="INCOMING"><orgName>Biological Sciences</orgName>
<desc><address><country key="US"></country>
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<desc><address><addrLine>1200 West Harrison St., Chicago, Illinois 60607</addrLine>
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</address>
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<country>États-Unis</country>
<placeName><settlement type="city">Chicago</settlement>
<region type="state">Illinois</region>
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<orgName type="university">Université de l'Illinois à Chicago</orgName>
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</author>
<author><name sortKey="Grosjean, Yael" sort="Grosjean, Yael" uniqKey="Grosjean Y" first="Yaël" last="Grosjean">Yaël Grosjean</name>
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<orgName>Centre des Sciences du Goût et de l'Alimentation [Dijon]</orgName>
<orgName type="acronym">CSGA</orgName>
<date type="start">2010-01-01</date>
<desc><address><addrLine>Université de Bourgogne - Bât. CSG - 9E Bd Jeanne d'Arc - 21000 Dijon</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www2.dijon.inra.fr/csga/</ref>
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<tutelles><tutelle name="UMR1324" active="#struct-92114" type="direct"><org type="institution" xml:id="struct-92114" status="VALID">          <orgName>Institut National de la Recherche Agronomique</orgName>
          <orgName type="acronym">INRA</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.inra.fr</ref>
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</tutelle>
<tutelle active="#struct-300270" type="direct"><org type="institution" xml:id="struct-300270" status="VALID">          <orgName>Université de Bourgogne</orgName>
          <orgName type="acronym">UB</orgName>
          <desc>            <address>              <addrLine>Maison de l'université - Esplanade Érasme - BP 27877 - 21078 Dijon cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.u-bourgogne.fr/</ref>
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        </org>
</tutelle>
<tutelle name="UMR6265" active="#struct-415469" type="direct"><org type="institution" xml:id="struct-415469" status="VALID"><orgName>Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement</orgName>
<orgName type="acronym">AgroSup Dijon</orgName>
<date type="start">2009-03-01</date>
<desc><address><addrLine>26 Boulevard du Dr Petitjean - BP 87999 - 21079 Dijon cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.agrosupdijon.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR6265" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
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          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Dijon</settlement>
<region type="region" nuts="2">Région Bourgogne</region>
</placeName>
<orgName type="university">Université de Bourgogne</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Bourgogne Franche-Comté</orgName>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1038/srep19692</idno>
<series><title level="j">Scientific Reports</title>
<idno type="ISSN">2045-2322</idno>
<imprint><date type="datePub">2016</date>
</imprint>
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</fileDesc>
<profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>evolutionary rate covariation</term>
<term>extracellular glutamate</term>
<term>genes</term>
<term>glial xct</term>
<term>in-vivo</term>
<term>juvenile-hormone</term>
<term>melanogaster</term>
<term>neuromuscular-junction</term>
<term>protein-protein interactions</term>
<term>synaptic vesicle</term>
</keywords>
</textClass>
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</teiHeader>
<front><div type="abstract" xml:lang="en">Changes in synaptic physiology underlie neuronal network plasticity and behavioral phenomena, which are adjusted during development. The Drosophila larval glutamatergic neuromuscular junction (NMJ) represents a powerful synaptic model to investigate factors impacting these processes. Amino acids such as glutamate have been shown to regulate Drosophila NMJ physiology by modulating the clustering of postsynaptic glutamate receptors and thereby regulating the strength of signal transmission from the motor neuron to the muscle cell. To identify amino acid transporters impacting glutmatergic signal transmission, we used Evolutionary Rate Covariation (ERC), a recently developed bioinformatic tool. Our screen identified ten proteins co-evolving with NMJ glutamate receptors. We selected one candidate transporter, the SLC7 (Solute Carrier) transporter family member JhI-21 (Juvenile hormone Inducible-21), which is expressed in Drosophila larval motor neurons. We show that JhI-21 suppresses postsynaptic muscle glutamate receptor abundance, and that JhI-21 expression in motor neurons regulates larval crawling behavior in a developmental stage-specific manner.</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region><li>Illinois</li>
<li>Pennsylvanie</li>
<li>Région Bourgogne</li>
</region>
<settlement><li>Chicago</li>
<li>Dijon</li>
<li>Pittsburgh</li>
</settlement>
<orgName><li>Université de Bourgogne</li>
<li>Université de Bourgogne Franche-Comté</li>
<li>Université de Pittsburgh</li>
<li>Université de l'Illinois à Chicago</li>
</orgName>
</list>
<tree><country name="France"><region name="Région Bourgogne"><name sortKey="Ziegler, Anna" sort="Ziegler, Anna" uniqKey="Ziegler A" first="Anna" last="Ziegler">Anna Ziegler</name>
</region>
<name sortKey="Berthelot Grosjean, Martine" sort="Berthelot Grosjean, Martine" uniqKey="Berthelot Grosjean M" first="Martine" last="Berthelot-Grosjean">Martine Berthelot-Grosjean</name>
<name sortKey="Geillon, Flore" sort="Geillon, Flore" uniqKey="Geillon F" first="Flore" last="Geillon">Flore Geillon</name>
<name sortKey="Grosjean, Yael" sort="Grosjean, Yael" uniqKey="Grosjean Y" first="Yaël" last="Grosjean">Yaël Grosjean</name>
<name sortKey="Maniere, Gerard" sort="Maniere, Gerard" uniqKey="Maniere G" first="Gérard" last="Maniere">Gérard Maniere</name>
<name sortKey="Simonnet, Megane" sort="Simonnet, Megane" uniqKey="Simonnet M" first="Mégane" last="Simonnet">Mégane Simonnet</name>
</country>
<country name="États-Unis"><region name="Illinois"><name sortKey="Augustin, Hrvoje" sort="Augustin, Hrvoje" uniqKey="Augustin H" first="Hrvoje" last="Augustin">Hrvoje Augustin</name>
</region>
<name sortKey="Clark, Nathan L" sort="Clark, Nathan L" uniqKey="Clark N" first="Nathan L." last="Clark">Nathan L. Clark</name>
<name sortKey="Featherstone, David E" sort="Featherstone, David E" uniqKey="Featherstone D" first="David E." last="Featherstone">David E. Featherstone</name>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Steinert, Joern R" sort="Steinert, Joern R" uniqKey="Steinert J" first="Joern R." last="Steinert">Joern R. Steinert</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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The Amino Acid Transporter JhI-21 Coevolves with Glutamate Receptors, Impacts NMJ Physiology, and Influences Locomotor Activity in [i]Drosophila[/i] Larvae

The Amino Acid Transporter JhI-21 Coevolves with Glutamate Receptors, Impacts NMJ Physiology, and Influences Locomotor Activity in [i]Drosophila[/i] Larvae

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